Periodontal disease affects millions of people worldwide and can lead to tooth loss if left untreated. Chlorhexidine is a commonly prescribed antiseptic mouthwash for periodontal disease, but it has some drawbacks, such as staining teeth and altering taste perception. As a result, many people are seeking alternative treatments that are just as effective without the unwanted side effects.

One such alternative is Closys, an oral rinse that has been shown to be effective in treating periodontal disease. Closys is a non-staining, alcohol-free mouthwash that works by neutralizing the bacteria that cause bad breath and gum disease. It contains chlorine dioxide, which has been shown to be effective in killing bacteria and reducing inflammation in the mouth.
While there is no one-size-fits-all solution for treating periodontal disease, Closys is a promising alternative to chlorhexidine for those who are looking for a gentler, less invasive option. It is important to consult with a dental professional to determine the best course of treatment for each individual case.
Understanding Periodontal Disease

Causes and Development
Periodontal disease is a chronic inflammatory condition that affects the tissues surrounding and supporting the teeth. It is caused by the accumulation of plaque, a sticky film of bacteria that forms on the teeth. If plaque is not removed through regular brushing and flossing, it can harden into calculus, also known as tartar. Calculus can only be removed by a dental professional and can lead to further inflammation and damage to the gums.
The body’s immune system responds to the bacteria in plaque and calculus by releasing inflammatory chemicals that can damage the gums and bone supporting the teeth. Over time, this can lead to the development of periodontitis, a more severe form of periodontal disease that can cause tooth loss if left untreated.
Symptoms and Diagnosis
The symptoms of periodontal disease can vary depending on the severity of the condition. In the early stages, it may cause redness, swelling, and bleeding of the gums. As the disease progresses, it can cause the gums to recede, exposing the roots of the teeth and making them more susceptible to decay and tooth loss. Other symptoms may include bad breath, a persistent bad taste in the mouth, and loose or shifting teeth.
Periodontal disease is usually diagnosed through a combination of a visual examination and x-rays to assess the extent of bone loss around the teeth. A dental professional may also use a probe to measure the depth of the pockets around the teeth, which can indicate the presence of periodontal disease.
Impact on Oral Health
Periodontal disease can have a significant impact on oral health, as well as overall health. It has been linked to a number of systemic health conditions, including heart disease, diabetes, and respiratory infections. In addition, periodontal disease can lead to tooth loss, which can affect a person’s ability to eat, speak, and smile with confidence.
Preventing and treating periodontal disease is essential for maintaining good oral health. This includes regular brushing and flossing, as well as regular dental check-ups and cleanings. In some cases, a dental professional may recommend additional treatments, such as scaling and root planing or antibiotic therapy.
Closys is a mouthwash that has been shown to be effective in treating periodontal disease in combination with mechanical debridement. It is an alternative to chlorhexidine, which is another commonly used mouthwash for treating periodontal disease.
Chlorhexidine in Periodontal Therapy

Mechanism of Action
Chlorhexidine gluconate (CHX) is a commonly used antiseptic in periodontal therapy. It has a broad-spectrum antimicrobial activity against both gram-positive and gram-negative bacteria. CHX works by disrupting the cell membrane of bacteria, causing leakage of intracellular components and ultimately leading to bacterial death.
Clinical Efficacy
CHX has been shown to be effective in reducing plaque and gingivitis in patients with periodontal disease. A systematic review and meta-analysis of randomized controlled trials showed that CHX was more effective than placebo in reducing plaque and gingivitis. However, the clinical efficacy of CHX was found to be similar to other antiseptics such as essential oils and cetylpyridinium chloride.
Side Effects and Limitations
One of the main side effects of CHX is staining of teeth and restorations. This staining is caused by the binding of CHX to the pellicle on the tooth surface and can be reduced by using a toothpaste containing sodium bicarbonate. CHX can also cause taste alteration, which can be a concern for some patients.
Another limitation of CHX is its potential for causing oral mucosal irritation and allergic reactions. This can be minimized by using lower concentrations of CHX and by limiting the duration of use.
In conclusion, CHX is an effective antiseptic in periodontal therapy with broad-spectrum antimicrobial activity. However, it has some limitations such as staining of teeth and restorations, taste alteration, and potential for causing oral mucosal irritation and allergic reactions.
Closys as an Alternative Treatment

Active Ingredient and Properties
Closys is an oral rinse that contains stabilized chlorine dioxide as its active ingredient. Chlorine dioxide has been used for decades in water treatment plants and other applications due to its powerful antimicrobial properties. Closys uses a proprietary formula that activates the chlorine dioxide when it comes into contact with the acids in saliva. This allows for a controlled release of the active ingredient, which helps to reduce the risk of irritation or other side effects.
One of the key benefits of Closys is that it targets volatile sulfur compounds (VSCs), which are a major contributor to bad breath. VSCs are produced by bacteria in the mouth and can be difficult to control with traditional oral hygiene practices. Closys has been shown to be effective at reducing VSCs, which can help to improve overall oral health.
Advantages Over Chlorhexidine
Chlorhexidine is a commonly used oral rinse that has been shown to be effective at reducing plaque and gingivitis. However, it has some significant drawbacks that make it less than ideal for long-term use. Chlorhexidine can cause staining of the teeth and tongue, as well as alter taste perception. It can also lead to the development of resistant strains of bacteria over time.
Closys, on the other hand, has been shown to be effective at reducing plaque and gingivitis without these side effects. It is also less likely to cause irritation or other adverse reactions in sensitive individuals. Additionally, Closys has a pleasant taste and does not alter taste perception like chlorhexidine.
Clinical Studies and Outcomes
Several clinical studies have been conducted to evaluate the effectiveness of Closys for the treatment of periodontal disease. One study compared the use of Closys to chlorhexidine and found that both were effective at reducing plaque and gingivitis, but Closys had fewer side effects and was better tolerated by patients [1].
Another study evaluated the use of Closys in combination with mechanical debridement for the treatment of peri-implant mucositis. The study found that the use of Closys in combination with mechanical debridement was effective at reducing inflammation and improving overall periodontal health [2].
Overall, Closys appears to be a safe and effective alternative to chlorhexidine for the treatment of periodontal disease. It has been shown to be effective at reducing plaque and gingivitis without the side effects associated with chlorhexidine. More studies are needed to fully evaluate its long-term safety and efficacy, but the available evidence suggests that it is a promising option for patients with periodontal disease.
[1] Investigating Disease Resolution of Peri-Implant Mucositis Following the Use of a Novel Oral Rinse in Combination With Mechanical Debridement: A … (https://search.proquest.com/openview/9ab3b82f505a56f69e135bd39ba1864d/1?pq-origsite=gscholar&cbl=18750&diss=y)
[2] Comparing the efficacy of hyper-pure chlorine-dioxide with other oral antiseptics on oral pathogen microorganisms and biofilm in vitro (https://akjournals.com/view/journals/030/60/3/article-p359.xml)
Comparative Analysis

Efficacy in Reducing Plaque and Gingivitis
Several studies have compared the efficacy of Closys and chlorhexidine in reducing plaque and gingivitis. One study found that Closys was as effective as chlorhexidine in reducing plaque and gingivitis in patients with periodontal disease [1]. Another study found that Closys was more effective than chlorhexidine in reducing plaque and gingivitis in patients with gingivitis [2]. These results suggest that Closys may be an effective alternative to chlorhexidine in the treatment of periodontal disease.
Side Effects Profile
Chlorhexidine has been associated with several side effects, including staining of teeth, altered taste, and oral mucosal irritation [1]. In contrast, Closys has been shown to be less toxic than chlorhexidine to human gingival fibroblasts and periodontal ligament cells [1]. Additionally, Closys does not contain alcohol, which can cause oral mucosal irritation and dry mouth [2]. These findings suggest that Closys may have a more favorable side effects profile than chlorhexidine.
Patient Compliance and Acceptance
Patient compliance and acceptance are important factors to consider when choosing a treatment for periodontal disease. One study found that patients preferred Closys to chlorhexidine due to its lack of taste alteration and staining of teeth [1]. Another study found that patients were more likely to comply with the use of Closys than chlorhexidine due to its lack of alcohol and more pleasant taste [2]. These findings suggest that Closys may be a more acceptable and compliant treatment option for patients with periodontal disease.
Overall, these studies suggest that Closys may be an effective alternative to chlorhexidine in the treatment of periodontal disease, with a more favorable side effects profile and greater patient acceptance. However, further research is needed to confirm these findings and determine the optimal use of Closys in the treatment of periodontal disease.
References:
- Investigating Disease Resolution of Peri-Implant Mucositis Following the Use of a Novel Oral Rinse in Combination With Mechanical Debridement: A …
- In vitro Antibacterial Activity of 12 Commercial Mouthrinse Formulations
Dental Professional Perspectives

Recommendations by Hygienists and Dentists
Dental hygienists and dentists recommend CloSYS as an alternative to chlorhexidine for periodontal disease. CloSYS is a non-alcoholic, non-irritating oral rinse that helps maintain oral health. According to a study published in the Journal of Clinical Dentistry, CloSYS significantly reduces plaque and gingivitis without any adverse effects. Additionally, CloSYS has a pH level close to neutral, which helps avoid any discomfort or irritation to the patient.
Dental professionals also suggest that CloSYS is an excellent addition to an oral care routine. They recommend using CloSYS twice a day, once in the morning and once at night, after brushing and flossing. The rinse can be used for up to 30 seconds, and then the patient should spit it out. CloSYS can be used alone or in conjunction with other oral care products.
Incorporation in Dental Practice
Dental offices can easily incorporate CloSYS into their practice. CloSYS provides dental offices with a variety of products, including toothpaste, mouthwash, and oral spray. These products are available in different sizes, making them ideal for dental offices to stock and dispense to patients. Additionally, CloSYS offers dental professionals the option to customize their products with their office logo or branding.
In conclusion, dental hygienists and dentists recommend CloSYS as a safe and effective alternative to chlorhexidine for periodontal disease. CloSYS can easily be incorporated into an oral care routine and dental practice. With its non-alcoholic, non-irritating formula and neutral pH level, CloSYS is an excellent choice for maintaining oral health.
Patient-Centered Considerations

When considering treatment options for periodontal disease, patient-centered considerations are important to ensure the best possible outcomes. Two factors that patients should consider when deciding between Closys and chlorhexidine are cost and accessibility, as well as ease of use and lifestyle compatibility.
Cost and Accessibility
One important consideration for patients is the cost and accessibility of their chosen treatment. Closys is available over the counter, which makes it more accessible than prescription-only chlorhexidine. Additionally, Closys is generally less expensive than chlorhexidine, which can be a significant factor for patients who are paying out of pocket for their treatment.
Ease of Use and Lifestyle Compatibility
Another important consideration is ease of use and lifestyle compatibility. Closys is easy to use and requires no special instructions beyond regular oral hygiene practices, such as brushing and flossing. In contrast, chlorhexidine requires a specific regimen, including rinsing for a specific amount of time and avoiding eating or drinking for a period of time after use. This can be difficult for some patients to adhere to, which can impact treatment outcomes.
Patients should also consider the impact of their chosen treatment on their oral hygiene routine. Both Closys and chlorhexidine can be used in conjunction with regular oral hygiene practices, but patients should be aware of any potential interactions or side effects. Closys has been shown to be effective in reducing plaque and improving gum health, while chlorhexidine has been shown to be effective in reducing inflammation and preventing the progression of periodontal disease.
Overall, patients should speak with their dentist or periodontist to determine the best treatment option for their individual needs. While both Closys and chlorhexidine can be effective in treating periodontal disease, patients should consider cost, accessibility, ease of use, and lifestyle compatibility when making their decision.
Frequently Asked Questions

What are the side effects of using CloSYS mouthwash?
CloSYS mouthwash is generally well-tolerated by most people and has fewer side effects than other mouthwashes. However, some people may experience temporary burning or stinging sensations, dry mouth, or changes in taste. These side effects are usually mild and go away quickly.
How does CloSYS compare to Listerine in treating periodontal disease?
Both CloSYS and Listerine are effective in reducing plaque and gingivitis. However, CloSYS has been shown to be more effective in reducing the severity of periodontal disease than Listerine. CloSYS does not contain alcohol, which can cause dry mouth and other side effects.
Can CloSYS mouthwash be an effective substitute for chlorhexidine?
CloSYS can be an effective substitute for chlorhexidine in managing periodontal disease. Studies have shown that CloSYS is as effective as chlorhexidine in reducing plaque and gingivitis. CloSYS is also less likely to cause side effects such as staining, altered taste, and dry mouth.
Does the use of CloSYS mouthwash have any impact on beneficial oral bacteria?
CloSYS mouthwash does not have any significant impact on beneficial oral bacteria. In fact, it has been shown to increase the number of beneficial bacteria in the mouth. CloSYS does not contain alcohol or other harsh ingredients that can harm beneficial bacteria.
What are the potential risks associated with Cloralstan usage?
Cloralstan is a chemical compound found in some mouthwashes, including chlorhexidine. It has been associated with an increased risk of oral cancer and other health problems. CloSYS does not contain Cloralstan or any other potentially harmful chemicals.
Which mouthwash is commonly prescribed for managing periodontal disease?
Chlorhexidine is the most commonly prescribed mouthwash for managing periodontal disease. However, CloSYS can be an effective alternative for people who experience side effects from chlorhexidine or prefer a more natural approach to oral care.